Here are a few examples of our services. More information and price indications on request
EXAMPLE. A client looked for a novel strategy to identify virulence genes from a bacterium of which the genome sequence was available but virulence genes had not been identified. A new technique was developed to assess polymorphisms without knowing the phenotype of these genes. The project resulted in a complete new area of research. EXAMPLE. An on-site consulting session was organised for the research group of a medical microbiology department. Each researcher presented his or her work in a 1-hour face-to-face meeting in which practical problems and future strategies were discussed. Follow-up advise was provided at need by Email and web-based conferencing. As a result of fruitful discussions, several projects progressed more rapidly and a number of scientific publications were written in collaboration. EXAMPLE. A group of enthousiast researchers had sequenced a highly variable region of a human pathogen. The sequences told their story, but what did it all mean? From a wealth of information, the most important data were subtracted, ordened, and interpreted for clinical relevance, and subsequently published in a high-standard journal.
EXAMPLE. A client was interested in patterns observed in the ORF distribution of a particular micro-organism and was interested in the biological relevance of the observations. The patterns were analyzed and correlated to the biological properties of the organism. This opened a new field of computer-based research. EXAMPLE. A client had performed subtractive hybridization with two strains of one bacterial species. The resulting clones were partially sequenced. Most gene fragmens had no or only weak hits in BLAST. A thorough analysis was performed to identify the top 10 candidates to focus the wet-lab research. EXAMPLE. A client wanted to identify particular gene combinations in a bacterial genome responsible for a particular, complex, phenotype. Total bacterial genome comparison was performed with PSI-BLAST and related to known phenotypes to deduce this complex information.
EXAMPLE. A client demanded a thorough literature review on bacterial virulence, and the spread of virulence genes in natural bacterial populations. This resulted in a report reviewing over 300 references. The report was printed on CD, with all reference links providing the abstract of the cited papers. EXAMPLE. A company had the impression their product was not receiving a fair press. A literature search was conducted to produce an unbiased opinion. The results were not completely what the company had wanted to hear, but sometimes an independent mind is all it needs to be put on the right track. EXAMPLE. A governmental agency wanted an update on genetically modified animals in the food chain. An extensive literature search project was summarized in a comprehensible report, written for the non-expert.